Malaysian Journal of Analytical Sciences Vol 25 No 2 (2021): 257 - 267

 

 

 

 

A BRIEF REVIEW ON THE THIAZOLE DERIVATIVES: SYNTHESIS METHODS AND BIOLOGICAL ACTIVITIES

 

(Ulasan Ringkas Terbitan Tiazol: Kaedah Sintesis dan Aktiviti Biologi)

 

Iswatun Hasanah Abdullah Ripain and Nurziana Ngah*

 

Department of Chemistry, Kulliyyah of Science,

International Islamic University Malaysia, Kuantan Campus Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia

 

*Corresponding author:  nurziana@iium.edu.my

 

 

Received: 27 January 2021; Accepted: 24 March 2021; Published:  25 April 2021

 

 

Abstract

Thiazole is one of the leading heterocyclic five-membered ring compounds that contain sulphur atoms at position 1 and nitrogen atoms at position 3. Many of its natural and synthetic derivatives possess diverse biological activities. In drug research development, the substituent at thiazole ring was modified to generate new molecules with potent biological activities. This review describes the chemistry of thiazole, the synthetic pathway of thiazole, and their biological activities that could benefit other researchers to design new molecules of thiazole derivatives with more potent biological activities.

 

Keywords:  thiazole, chemistry, synthetic pathway, biological activities

 

Abstrak

Tiazol merupakan sebatian heterosiklik bergelang lima yang mempunyai atom sulfur dan nitrogen pada kedudukan masing-masing 1 dan 3 pada gelang tersebut. Sebatian ini, samada semulajadi atau sintetik banyak diaplikasikan dalam pelbagai bidang biologi. Di dalam kajian penghasilan ubatan baru, banyak terbitan baru sebatian tiazol dapat dicipta dengan menukarkan  pelbagai penukarganti yang sesuai terhadap gelang tiazol tersebut supaya mempunyai potensi dalam aktiviti biologi. Di dalam kajian ini, kimia sebatian tiazol, laluan sintetik tiazol dan aplikasi sebagai bahan antibiologi dibincangkan. Diharap, ulasan ini dapat memberi manfaat kepada penyelidik yang ingin mengkaji dengan lebih mendalam potensi sebatian tiazol sebagai agen biologi.

 

Kata kunci:  tiazol, kimia, laluan sintetik, aktiviti biologi       

 

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