Malaysian Journal of Analytical
Sciences, Vol 27
No 3 (2023): 563 - 572
CHROMATOGRAPHIC METHODS
FOR THE DETERMINATION OF DICLOFENAC IN HUMAN BIOLOGICAL SAMPLES: A MINI REVIEW
(Kaedah Kromatografi Untuk Penentuan Diclofenac Dalam Cecair
Tubuh Manusia:
Satu Ulasan Mini)
Sabreenna Marsya Djuli1, and Normala Abd Latip1,2*
1Faculty of Pharmacy,
Universiti Teknologi MARA,
42300 Bandar Puncak Alam, Selangor,
Malaysia
2Integrative Pharmacogenomics
Institute (iPROMISE),
Universiti Teknologi MARA,
42300 Bandar Puncak Alam, Selangor, Malaysia
*Corresponding
author: drnormala6351@uitm.edu.my
Received: 2 February 2023; Accepted: 18
April 2023; Published: 23 June 2023
Abstract
Diclofenac is a non-steroidal anti-inflammatory
drug (NSAID) used to treat pain and inflammatory disorders. Due to a general
increase in the usage of pharmaceuticals and incomplete removal of such
compounds from through treatment of wastewater, drugs such as diclofenac have
been labelled as emerging contaminants of concern. This review covers the
chromatographic methods that have been reported in recent literature for the
determination of diclofenac in biological fluids of humans. This could be
beneficial for researchers interested in the detection and quantification of
diclofenac for epidemiological studies to determine the extent of contamination
within human populations.
Keywords: diclofenac, chromatographic methods, human fluids
Abstrak
Diclofenac
adalah sejenis ubatan anti-keradangan bukan steroid yang digunakan bagi merawat
kesakitan dan gejala keradangan. Peningkatan penggunaan farmaseutikal dan
kegagalan penyingkiran sepenuhnya sebatian farmaseutikal dari rawatan sisa buangan
mengakibatkan diclofenac dilabel sebagai bahan pencemar baru muncul. Ulasan ini
meliputi kaedah kromatografi yang telah dilaporkan dalam penerbitan terkini
untuk penentuan kepekatan diclofenac dalam sampel cecair tubuh manusia. Ulasan
ini diharap memberi faedah buat penyelidik yang melakukan pengesanan dan
pengkuantitian diclofenac untuk kajian epidemiologi bagi penentuan kesan
pencemaran ini kepada populasi manusia.
Kata kunci: diclofenac, kaedah kromatografi,
sampel cecair manusia
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