(Kajian awal
penyebaran α-mangostin dalam sistem mikrogel PNIPAM)
School of
Chemical Sciences and Food Technology,
Faculty of
Science and Technology,
Universiti
Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
*Corresponding author:
bohari@ukm.my
Abstract
α-mangostin is a natural product
containing xanthone core structure
isolated from mangosteen rind. It is known to possess many biological
properties including antibacterial, antiviral, anti-inflammatory and
antioxidant activities. Some food products such as XanGo Mangosteen Juice,
Vemma Mangosteen Juice Nutrition Supplement and Nanoxan Gold containing
α-mangostin are readily available in the market. Spectroscopic study
showed that α-mangostin exhibits a maximum fluorescence peak at
approximately 500 nm which can be utilized for internal irradiation and
photoimaging purposes. It may also have an effect on a formulated products
containing α-mangostin. However, the emission peak for α-mangostin
was not observed in the PNIPAM microgel solution. In the present study,
α-mangostin was added into PNIPAM microgel solution. The dispersion of
α-mangostin was studied by using Dynamic Light Scattering (DLS) and
Transmission Electron Microscope (TEM).
Keywords: α-mangostin, PNIPAM microgel,
Dynamic Light Scattering and Transmission Electron Microscope
References
1.
Yates,
P., Stout, G.H., 1958. The structure of mangostin. J. Am. Chem. Soc. 80, 1691–1700.
2.
Jung,
H.A., Su, B.N., Keller, W.J., Mehta, R.G., Kinghorn, D., 2006. Antioxidant
Xanthones from pericarp of Garcinia mangostana (Mangosteen). J. Agric. Food.Chem.54: 2077–2082.
3.
Chomnawang,
M. T., S. Surassmo, V.S. Nukoolkarn and W. Gritsanapan. 2005. Antimicrobial
effects of Thai medicinal plants against acne-inducing bacteria. J. Ethnopharmacol.101: 330-3.
4.
Chen,
L.G., L.L. Yang and C.C. Wang. 2008. Antiinflammatory activity of mangostins
from Garcinia mangostana. Food
Chem. Toxicol 46: 688-693.
5.
Gopalakrishnan,
G., B. Banumathi & G. Suresh. 1997. Evaluation of the antifungal activity
of natural xanthones from Garcinia mangostana and their synthetic
derivatives. J. Nat. Prod.60:
519-524.
6.
Iinuma,
M., H. Tosa, T. Tanaka, F. Asai, Y. Kobayashi, R.Shimano and K. Miyauchi. 1996.
Antibacterial activity of xanthones from guttiferaeous plants against
methicillin-resistant Staphylococcus aureus. J. Pharm. Pharmacol. 48: 861-865.
7.
Siriwan,
K. 2004. Using chitosan for improving the dyebility of cotton fabrics with
mangosteen rind dye. J.Sci.Res.Chula.Univ.:
Vol29(2).
8.
Fugal,
K. B., McCausland, T. L., Kou, X., & Keller, W.J. 2006. Neutraceutical
composition containing mangosteen pericarp extract. United States Patent Application Publication. Paten Pub.No.: US
2006/0088643.
9.
Sobotta,
R. & Ignatow, H. P. 2006. Process for isolating of alpha-mangostin. United States Patent Application
Publication. Paten Pub.No.:US 2006/0014967.
10.
Dirk
Schmaljohann. 2006. Thermo- and pH responsive polymers in drug delivery. Advanced Drug Delivery Reviews
58:1655–1670.
11.
Pedraza-Chaverri,
J., Reyes-Fermi, L. M., Nolasco-Amalaya E. G., Orozco-Ibarra, M.,
Medina-Campos, O. N., Gonzalez-Cuahutencos, O., Rivero-Cruz, I., Mata, R. 2008.
ROS Scavenging Capacity and Neuroprotective Effect of α-mangostin against
3-nitropropionic acid in Cerebellar Granule Neurons. Exp Toxicol Pathol 11:002.
12.
R. J. Hall, V. T. Pinkrah, B. Z. Chowdhry and M. J. Snowden. 2004. Heteroaggregation
studies of mixed cationic co-polymer/anionic homopolymer microgel dispersions. Colloids Surf.(A)233: 25–38.
13.
Yu,
L., Zhao M., Yang, B., Zhao, Q. & Jiang, Y. 2007. Phenolics from hull of
Garcinia mangostana fruit and their antioxidant activities. Food Chemistry 104 : 176–181.
14.
Tam,
K. C., Ragaram, S., Pelton, R. H. 1994. Interaction of surfactants with
poly(N-isopropylacrylamide) microgel latexes. Langmuir 10: 418-422.
15.
Neraspuri,
V., Keddie, J.L., Vincent, B., Bushnak, I. A. 2006. Swelling and deswelling of
adsorbed microgel monolayers triggered by changes in temperature, pH, and
electrolyte concentration. Langmuir
22: 5036-5041.
16.
Gao,
Y., Au-Yeung S. C. F., Wu, C. 1999. Interaction between Surfactant and
Poly(N-vinylcaprolactam) Microgels. Macromolecules
32: 3674-3677.