The Malaysian Journal of Analytical Sciences Vol 15 No 1 (2011): 93 – 100

 

 

 

SYNTHESIS, CHARACTERIZATION AND NEUROTOXIC EFFECT OF SCHIFF BASE LIGANDS AND THEIR COMPLEXES

 

Ahmad Fauzi Abu Bakar¹*, Hadariah Bahron¹, Karimah Kassim¹, Mazatulikhma Mat Zain²

 

¹Department of Chemistry, Faculty of Applied Sciences,

²Institute of Science (IOS),

Universiti Teknologi MARA

40450 Shah Alam, Selangor, Malaysia

 

*Corresponding author: fauzi_charming@yahoo.com

 

 

Abstract

Two ligands and eight complexes are successfully synthesized by reacting 1,8-diaminonapthelene with aldehyde/ketone derivatives in 1:2 ratio for ligand formation and 1:1 ratio for complex formations. The compounds are characterized through CHN elemental anaysis, IR spectroscopy, ¹H NMR spectroscopy, melting point and magnetic susceptibility determination. The neurotoxicity of compounds is evaluated using neuroblastoma SH-SY5Y cell lines and it was indicate the cells were non-toxic either for ligands and complexes after 24 hours exposure.

 

Keywords: Schiff base, 1,8-diaminonaphthalene, neurotoxicity, SH-SY5Y cell lines

 

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